Arthropod-borne viruses (arboviruses) are viruses transmitted to plants and animals by insect vectors, such as mosquitoes and ticks. In human and animal populations around the world arboviruses such as West Nile virus continue to cause significant morbidity and mortality. To date, research efforts around these viral diseases have focused almost entirely on humans. There is however another important aspect to the disease dynamics, which has not been addressed, and that is the effect of these viruses on the insects that transmit them. The insect immune system shares many features with the human immune system yet very little is known about how insects regulate viral infections. Research has shown that arboviruses somehow evade the insect’s immune system yet are capable of transmitting the viruses to other hosts. Dawn Cooper is examining what factors viruses use to develop in insect vectors and the factors that insects use to kill viruses. Her research focuses on characterizing the immune responses expressed in response to the virus infection of Aedes aegypti, a major vector of arboviruses. Ultimately information gained through this study will identify the novel fighting components of the insect immune response which may be exploited to reduce transmission or develop drugs to treat human infections.
Year: 2005
New routes to sialidase inhibitors: Synthesis, characterization, and evaluation of novel sialic acid derivatives
For many people, infection with the influenza virus results in several days of illness. Yet, each year, the virus is responsible for approximately one million deaths worldwide. Vaccines are the most common preventive treatment, but they only protect vaccinated individuals against those strains identified by the World Health Organization as being the most virulent in any given season. When a new strain of influenza appears against which humans have no immunity – as occurred with the Spanish flu pandemic of 1918 (which killed 20 million people worldwide), the Asian flu pandemic of 1957, and the Hong Kong flu pandemic of 1968 – the result is a pandemic that could infect and kill hundreds of millions of people worldwide. Better treatments and preventative measures to fight influenza infection are needed to counter this threat. There are currently two major anti-influenza drugs on the market that selectively inhibit a viral enzyme that is critical to spreading infection. While these drugs are effective, the influenza virus is resilient and by mutating can develop drug-resistant strains. Ivan Hemeon is researching the development of new anti-influenza compounds that have a much lower risk of generating resistant strains. Hopefully, people treated with these compounds would experience less severe symptoms and recover faster without the risk of harbouring resistant strains that could be passed on to others, particularly those made more vulnerable due to compromised immune systems.
The construct, structural and predictive validity of the Hare Psychopathy Checklist, Youth Version in adolescent females: Informing the assessment of risk for violence in girls
Aggressive and violent behaviour among female youth has emerged as a pressing social issue. Girls are entering the juvenile justice system for violent offenses at substantially higher rates than five or ten years ago. Unfortunately, our ability to gauge risk for violence among female youth is less than optimal, mainly because research has focused on identifying risk factors that predict violence and aggression in boys. Consequently, unique risk factors in girls may go undetected. Psychopathy is a powerful predictor of future violence in adult male prisoners, and is characterized by a callous disregard for others, a lack of empathy, and a propensity to highly impulsive and irresponsible behaviour. Despite the important role of psychopathy in violence risk prediction, little research has examined whether the construct of psychopathy applies to females, and virtually no studies have focused on female adolescents. Stephanie Penney is investigating how well psychopathy predicts future violence in girls compared to boys. Stephanie is examining how development, early socialization and environmental influences converge to create risk for females. This research will identify unique risk factors that predispose girls to aggressive and violent behaviour, and can be used to develop early intervention programs to reduce violence among high-risk girls.
Bringing risk prevention models into the bedroom: Sex appraisals, coping and their roles in condom use consistency
HIV transmission remains a threat in Canada and around the world. Men who have sex with men account for 41 percent of all new cases of HIV in Canada, and continue to be the largest proportion of new cases. However, recent trends suggest nearly 30 percent of new HIV cases occur among heterosexuals following sexual contact. Although new HIV drugs have brought hope to patients, they have also lessened the perception of HIV risk. In fact, new cases of HIV infection increased 17 percent in 2002, compared to 2000. Eli Puterman is developing a new model to predict and understand safe sex practices in two at-risk groups: heterosexuals with multiple partners, and men who have sex with men. While present HIV prevention models can predict the intention to use condoms, they are less successful at predicting whether condom use will actually occur, because they do not consider the uniqueness of each sexual encounter. Instead, Eli is investigating how individuals appraise and respond to HIV risk in different sexual situations over time. This research could provide a new model for HIV prevention strategies both within Canada and other developed countries.
The effects of individual, educational, and organizational factors on the job satisfaction, social adjustment, and career turnover of newly graduated registered nurses
Registered nurses (RNs) account for 75 percent of health care professionals. Statistics Canada predicts that demand for nursing services is expected to rise as much as 46 percent by 2011. But new nurses are leaving at an alarming rate: 15 to 21 percent of newly qualified RNs are lost to other careers or immigration. Action is needed to meet projected needs for nursing services, but little is known about the factors that affect nurses’ career decisions. Angela Wolff is surveying student nurses about the individual, educational and organizational factors that influence job satisfaction, social adjustment to the workplace, and career choices. Angela is evaluating whether professional autonomy, nursing control over the practice environment, and open, effective channels of communication are directly related to job satisfaction and commitment. This research will identify barriers to integrating new RNs into the workforce, and ways to develop a supportive work environment for beginning practitioners. Ultimately, these strategies could enhance recruitment and retention of new nurses to help address an impending shortage of nursing staff in Canada.
Non-surgical cosmetic procedures: health, body image and aging
Non-surgical cosmetic procedures (chemical peels, botox injections, laser hair removal, injectable fillers) are becoming more common than cosmetic procedures (breast augmentation, face lifts, liposuction). Non-surgical procedures are less expensive than cosmetic procedures and thus accessible to more people. To date, research into the perception and experience of non-surgical procedures, which are often viewed as more acceptable, less intrusive and medically risky, have largely been ignored. Dr. Laura Hurd Clarke is examining the perceptions and experiences of women aged 50+, both users and non-users of non-surgical cosmetic procedures as well as the perspectives of physicians who provide the treatments. She is interested specifically in analyzing the relationship between women’s attitudes towards non-surgical cosmetic procedures and their perceptions of health, healthy living, aging and body image. Results from her research will provide insights into the changing norms and social acceptance of the ‘medicalization’ of age-related appearance and a better understanding of the continued blurring of the relationship between health and beauty in contemporary society.
Molecular characterization of Ahi-1, a novel signaling molecule with an SH3 and multiple WD40-repeat domains, in normal and leukemic hematopoiesis
Because many forms of leukemia originate in blood stem cells, uncovering the changes that occur in these cells is crucial to understanding how these diseases develop and progress. Dr. Xiaoyan Jiang is studying Ahi-1, a newly-discovered oncogene (cancer causing gene) that is involved in murine leukemia development (leukemia in mice) and shows abnormal expression in human leukemic cells, including leukemic stem cells from patients with chronic myeloid leukemia and Sezary cancer cells from patients with cutaneous T-cell lymphoma. Her research team recently found that over-expression of Ahi-1 gene alone can cause leukemia in mouse models and suppression of Ahi-1 gene can normalize its transforming activity in human leukemia cells, a strong indicator that Ahi-1 is likely to be an important new oncogene involved in the development of leukemia in humans. Dr. Jiang’s research will explore the normal function(s) of Ahi-1 in the development of blood cells, and how this is altered when cells become leukemic. This research will also begin to identify new intracellular molecules that interact with Ahi-1 and the cellular and molecular pathways through which these interactions occur. Understanding how and by which pathways Ahi-1 contributes to the development of leukemia may provide important new molecular targets for the development of targeted cancer treatment that will be more effective and have fewer side effects than currently used chemotherapy.
Creation and function of neighborhoods in eukaryotic chromosomes: regulation by SWR1-Com, a desposition complex for histone variant H2A.Z
Chromatin is the complex of DNA and protein material that make up chromosomes, home to the genetic code. The basic unit of chromatin is the nucleosome, a fundamental building block consisting of DNA wrapped around an octamer of histone proteins. A large number of proteins involved in cancer development and the genetic susceptibility to devastating diseases such as Ataxia Telangiectasia (a progressive immunological and neurological disorder) act through modification of chromatin structures and interfere with normal chromatin function. Differences in chromatin structures between adjacent regions specify the properties of larger macrodomains called neighbourhoods. The shape and structure of these neighbourhoods influence chromosome behavior, while complex regulatory mechanisms that ultimately involve chromatin ensure that each cell expresses only the appropriate genes, duplicates its genome with high fidelity, divides only when required, all while combating constant assaults on its DNA. Failure in any of the mechanisms regulating these events can lead to disease. These chromatin structures themselves can also be inherited, creating an additional complex set of influences that are crucial for the identity and activity of the cell. The molecular biology of chromatin structures and their role in chromosome biology and genome function in health and disease is the focus of Michael Kobor’s research. Specifically, he is studying a unique chromosomal neighbourhood containing a specialized histone variant known as H2A.Z, which is deposited into chromatin by a large protein complex. Using innovative genome-wide approaches, Dr. Kobor’s team aims to uncover the rules and principles of histone variant function.
Pharmacist identification of new, diagnostically confirmed osteoarthritis (PHIND-OA)
Knee osteoarthritis is the most common cause of disability in older adults. There are three million Canadians currently afflicted with this condition, and it’s predicted that this number will increase by 50 per cent by 2020. The costs of medical care, drugs, and lost wages resulting from this disability is a major economic burden in Canada. Several research studies have demonstrated the benefit of non-drug therapy such as education and exercise for people with knee osteoarthritis. However, many individuals remain undiagnosed for their condition and don’t receive appropriate interventions. Dr. Carlo Marra is researching the potential of pharmacists, who are highly accessible health care practitioners, to help identify people with knee osteoarthritis by using a simple screening questionnaire. Next, he will investigate whether pharmacists can initiate an intervention that brings together patient, physiotherapist, and family practitioner to improve physical function, minimize pain, and reduce the economic burden of this disease. In addition, regular follow-ups will occur to assess and encourage compliance with the intervention, assess outcomes and answer any questions. Dr. Marra anticipates his research will demonstrate the value of this innovative, cost-effective strategy to improve outcomes and quality of life for people with knee osteoarthritis.
Primary health care for Chinese and South Asians: continuous, accessible, and timely
Recent years have seen increasing concern about access to and quality of primary health care in Canada. A substantial amount of provincial and federal funding has gone into revitalizing the primary health care system. The current tools used to assess how the primary health care system works for consumers (such as questionnaires) were originally developed primarily with well-educated, English-speaking Whites of European descent. British Columbia is home to the second largest immigrant population in Canada, where approximately 50 per cent of all BC immigrants are from Asia and one in every ten cannot speak, write, or understand English. Currently, little is known about whether current assessment tools are valid across different ethno-cultural groups who may not speak English. In addition, existing assessment tools may not adequately reflect the issues and concerns about primary health care that are important to different ethno-cultural populations. Dr. Sabrina Wong is studying the dimensions of primary health care that are important to adults from two of the largest ethno-cultural groups living in BC: Chinese and South Asians, who speak Cantonese or Punjabi, respectively. Through focus groups and telephone surveys, she is identifying what dimensions are addressed in existing assessment tools, and what needs to be modified for these ethno-cultural groups. Ultimately, Dr. Wong hopes that her research will result in an assessment tool of primary health care that is equally valid and reliable across English, Cantonese, and Punjabi speaking populations.