Research Location: University of British Columbia - Point Grey

An estimated 100,000 Canadians have Parkinson’s disease, a neurodegenerative disorder that affects the body and brain, causing tremors, stiffness and impaired mobility. Dopamine is a chemical produced in the brain to carry signals between nerves. Parkinson’s develops when cells that produce dopamine die. Researchers have yet to determine what triggers the onset of Parkinson’s. Although a small proportion of cases seem to run in families, research indicates the explanation may lie in individual environmental and lifestyle exposures. For example, workplace exposure to chemicals such as pesticides, heavy metals and solvents may increase the risk of developing Parkinson’s. In one of the largest studies to examine Parkinson’s disease, Anne Harris is investigating whether exposure to the “whole-body vibration” workers can experience operating heavy machinery also elevates risk. Previous studies have shown that traumatic head injury from boxing and other activities can damage the part of the brain that produces signals crucial to mobility and brain function. Harris wants to determine whether the accumulation of smaller injuries over time from whole-body vibration also damages this part of the brain. Her findings could lead to new methods for preventing and treating Parkinson’s disease.

Autism has increased 700 per cent in the last decade. The developmental disorder is characterized by severe difficulties with social interaction and communication, an extremely limited range of activities and interests, and often by the presence of repetitive behaviors. A recent study showed autism spectrum disorders (ASD) are the most costly of all childhood disorders in terms of prevalence, outcome, response to treatment, economic cost and family stress. The ability to recognize and understand the constantly-fluctuating emotional expressions of the human face and their associated mental states usually develops in the first year of life. Research has shown that these abilities are seriously impaired in individuals with autism. The causes of this impairment are not yet understood, and although researchers have put forward a variety of explanations, there has been no definitive answer. Based on her past research, Lisa Jefferies is implementing a new approach to the study of person perception in individuals with low to severe autism spectrum disorder and a milder variant known as Asperger’s Syndrome. Jefferies’ approach is based on computer-generated, human-like “”talking heads”” that allow each component of an expression to be controlled and manipulated independently. She aims to use this tool to understand the root of face-perception deficits in children with autism. Jefferies also believes the talking heads will provide an ideal format for an intervention technique, as they could be programmed to focus on critical combinations of facial actions. Her ultimate goal is to develop new knowledge that will contribute to the design of more effective intervention and training to improve the social intelligence of individuals diagnosed with ASD.

Numerous studies on the relationship between spirituality and mental and physical health have demonstrated that spiritual coping is an effective way of dealing with stress. Most research in this area has been conducted with members of ethnic and religious majorities. But little is known about how ethnic and religious minorities employ faith in coping with stress. Derrick Klaassen is examining the spiritual coping practices of Portuguese immigrants to British Columbia. Susan James and her colleagues at the University of British Columbia demonstrated that many of these immigrants suffer from a culture specific disorder termed agonias, translated as “”the agonies””. North American health care providers have generally misdiagnosed this problem as indigestion rather than anxiety or stress, and as a result the treatments have remained ineffective. Klassen has two goals for his research. The first is to add to the understanding of effective intervention for agonias by exploring the various healing systems that Portuguese immigrants employ (e.g. mental/health systems, spiritual, community, and cultural resources). The second goal is to examine the ways in which Portuguese immigrants use spiritual strategies to cope with agonias. Klaassen’s research involves conducting focus groups and revising an existing assessment tool for this community. The resulting questionnaire will serve both practitioners and scholars in their investigations of the role of spirituality in coping with stress in Portuguese immigrants. This project is part of a multi-stage program of research that will formulate a culturally sensitive treatment manual for health providers.

Mounting evidence indicates that caring for a family member with a chronic illness not only reduces the quality of life for the caregiver, it also increases the caregiver’s risk of becoming ill. Little is known about the specific mechanisms by which caregiving impacts health and well-being. One important factor may be the caregiver’s ability to adjust personal family and career goals to meet the demands of the difficult situation. If a caregiver is able to let go of goals set before the diagnosis, such as getting a promotion at work or building a vacation home, he or she may have an easier time adjusting to this new role, and in turn, experience reduced distress and better physical health. Teresa Marin is examining the impact of tendencies to adjust goals on both psychological and physical well-being. Once she has determined the relationship between goal adjustment and health in the context of caregiving stress, it will be possible to apply this knowledge to clinical interventions designed to foster better coping skills among caregivers. This research follows Marin’s MSFHR-funded Master’s work, in which she analyzed the mental and physical health of spouses caring for cancer patients to determine the daily impact of expressing or suppressing their emotions.