The immune response is the set of defenses our bodies mount to counter harmful microbes. The innate immune response is our first line of defense, providing protection until the adaptive immune response is activated. Unfortunately, the innate immune response can also be a double-edged sword. It can spin out of control and cause an overwhelming immune response called sepsis, which is responsible for 200,000 deaths every year in the US. The innate immune response is initiated and regulated by complex signalling pathways of genes in our cells. These pathways identify which type of microbe is invading (bacteria or viruses, for example) and mounts appropriate responses. Dr. David Lynn is investigating the genes involved in the innate immune response, how they are turned on and off in particular infections, and what goes wrong in cases of sepsis. This work generates vast quantities of data, requiring computer-based approaches (bioinformatics) to understand and handle such large datasets. Lynn’s work integrates gene expression data with information about how genes and proteins are interconnected in our cells in signalling networks or pathways – providing new information about gene interconnections influence their regulation. He is also investigating the same networks and pathways in other species such as mouse and cow, determining the differences and similarities in their innate immune response. Lynn’s work will help identify potential therapeutic or drug targets that could help safely boost the immune response. It will also highlight cases where important immunological differences make animal models unsuitable for research on human immunity.
Research Location: Simon Fraser University
Redefining community resilience: community perspectives on the intersection of gender, mental health and adaptive capacity in the context of the Mountain Pine Beetle disaster
Much of British Columbia’s forests have been infested with the mountain pine beetle (MPB), an epidemic that is predicted to result in the loss of more than 80 per cent of the province’s pine forests by 2013. The MPB is also expected to result in the widespread loss of jobs, shifts in traditional resource cultures of affected communities, and an increased risk of forest fires and other natural disasters (e.g. slides, flooding). Gender is recognized as one of the most critical determinants of disaster-related vulnerability. Women and children are disproportionately affected by disasters, reporting higher rates of stress-related health problems (e.g., post-traumatic stress, anxiety, depression), an increased risk of sexual and domestic violence, greater economic marginalization, and substantial increases in their work. They are also less likely to be involved in community-based planning and decision-making processes. Dr. Robin Cox is analyzing individual and collective stressors associated with MPB in four forestry-dependent communities: Barriere/Louis Creek, Clearwater, Quesnel and Wells. She is piloting a community-based research strategy intended to engage affected residents in each community in a series of workshops and focus group interviews. The focus of these events is to identify and elaborate community-based definitions and strategies of resilience that reflect the specific cultural, social, and political contexts of participants. The proposed study will contribute to the development of knowledge around community resilience that integrates a gender perspective, and will lead to the development of policies and procedures that are relevant and responsive to different communities affected by MPB.
New Perspectives on Gender, Diversity, and Health Policy, Planning, and Services
The primary methods for identifying and responding to differences between men and women in the health context are gender-based and gender-sex-based analyses (GBA/GSBA). While these approaches are intended to consider diversity within each group, they do not always capture how gender interacts with other factors such as race/ethnicity, socio-economic status, sexual orientation, geography, ability and age. Not taking these factors into account in health planning, implementation and research can result in real economic and human costs for health care consumers. These include lost opportunities, ill health, suffering and perhaps overall, an ineffective and inequitable health care system. A key challenge facing researchers and policy makers is how to move beyond singular variables (e.g. gender) to understand the complex dynamics at play between gender and health. Dr. Olena Hankivsky is examining how GBA and GSBA are applied in health planning, services and policy in Canada, Sweden, the UK, Australia and the Ukraine. She is exploring innovative improvements for analyzing gender and diversity in a health context. In particular, Hankivsky is conducting a gender and diversity analysis of the most recent health reform initiative in British Columbia — The Conversation on Health. The findings could contribute to developing policy tools and interventions that will improve the effectiveness and efficiency of health services and programs for vulnerable and marginalized populations in BC, Canada, and internationally.
Testing the neural mechanisms of face processing in individuals with Autism: An MEG study
Autism is one of the most common neurological disorder affecting children, boys more commonly than girls, and usually appears in the first three years of life. It is thought that this disorder changes the way the brain processes information, causing cognitive impairments, deficits in communication and social understanding, and unusual behaviours. As a result, individuals with autism have difficulty paying attention to, and making sense of, social situations. Faces communicate a lot of social and emotional information, and are important to everyday interactions. As children develop, they typically orient to others’ faces from birth, becoming experts at recognizing faces. Conversely, children with autism are impaired at recognizing faces and facial expressions. Jennifer Barrie is using magnetoencephalography (MEG) — a non-invasive type of brain imaging that measures magnetic energy in the brain during cognition — to determine how neural processing differs in people with autism from those without the disorder. Barrie is examining when and where brain activation occurs when both groups look at faces. She anticipates that people with autism see only elements of faces, while others see the entire face, making faces easier to recognize. Using MEG, Barrie will assess whether these developmental differences can be changed with training. If so, these findings could shape future training programs that would enable people with autism to learn how to better perceive faces, improving their social and emotional functioning and quality of life.
Functional Analysis of Cilia's Role in Obesity
Cilia are hair-like structures that extend from nearly every cell in mammals. Non-motile cilia are involved in the sensations of the external environment, including light, smell and touch. Improper function of cilia is linked to a growing list of human disorders, including kidney disease, blindness, loss of the sense of smell, loss of left-right body asymmetry, male and female infertility, diabetes and obesity. Bardet-Biedl syndrome is an inherited disorder characterized by mental retardation as well as many of the symptoms linked with improper function of cilia. The known link between Bardet-Biedl syndrome and obesity demonstrates that dysfunction of cilia can predispose an organism to accumulate fat. How this occurs is unknown. However, people with this disorder are known to have an increased appetite and raised levels of certain types of proteins produced by fat cells that are involved in the regulation of appetite. Using a worm, Caenorhabditis elegans, which has sensory cilia remarkably similar to those of human cells, Michael Healey is aiming to clarify the role of ciliated nerve cells in regulating lipid levels. Healey is investigating whether all ciliary proteins or only a specific subset are involved in fat regulation, which ciliated nerve cells are important for fat regulation, and how cilia can control body weight. Ultimately, he aims to understand how Bardet-Biedl syndrome patients become obese, which will provide new insight into body weight control and the development of treatments for obesity.
Dimensionality and implications of reduced cognitive performance following kidney transplant
Chronic kidney disease (CKD) is an increasingly common disorder among middle-aged and older adults. More than 1,000 Canadians received kidney transplants in 1999, and there were more than three times that many on waiting lists. Deficits in memory and cognition are common in adults with chronic kidney disease and these worsen with increasing age. Cognitive abilities continue to be impaired following successful kidney transplant. However, decreased cognitive function in successful kidney transplant patients, which has vast implications on quality of life, has not been thoroughly examined. Theone Paterson is studying the everyday cognitive ability of renal transplant patients and how age, traditional and everyday measures of cognitive performance, and differing emotional states affect their quality of life and their ability to function in society on a daily basis post transplant. Specifically, Paterson’s research is looking at how these factors affect their ability to follow treatment regimens, such as taking medicines and following dietary restrictions. This work could lead to new approaches, including special training for healthcare providers in ways of supporting patients to better understand and remember aspects of treatment. Ultimately, the goal is to improve patients’ lives.
Nonverbal Emotion Processing Across Communication Channels
Nonverbal communication – facial expressions, gestures, posture, and intonation (tone of voice) – offers a rich source of information about a speaker’s intentions and moods. Recognizing and correctly interpreting these cues is important for social competence, but is challenging for people with autism and other developmental disorders that have deficits in nonverbal communication. Intonation and facial expressions represent the most prominent and biologically important nonverbal communication channels. These channels typically overlap in terms of the information they convey. While few studies have looked at the shared and unique brain mechanisms involved in these communication systems, some behavioural research suggests shared underlying mechanisms. Using magnetoencephalography, an imaging technique used to detect electro-magnetic and metabolic shifts occurring in the brain, Valery Sramko is studying both typically developing adults and those with autism spectrum disorder. Sramko is examining the mechanisms and brain areas shared by intonation and facial expression, which are deficient in people with autism, to shed light on nonverbal emotion processing. Her overall aim is to gain a better understanding of the processes and mechanisms involved in nonverbal communication, which could contribute to the development of potential interventions for people with autism and other developmental disorders.
Biomechanical energy harvesting
Electronic medical devices such as vital sign monitors, pacemakers and motorized prostheses are relied upon by people with disabilities, the elderly and others. However, all of these mobile devices are powered by batteries, which have limited energy storage, and add additional weight to the devices. Although substantial progress has been made in enhancing battery capacity, power requirements for the mobile devices are increasing faster than the improvements made in battery performance. Human power is an attractive energy source because of the ability for humans to convert food into mechanical power and the high mechanical power outputs attainable by humans. Human power is portable, environmentally friendly, and readily available for power-consuming applications that involve direct human use, such as prostheses. Qingguo Li is part of an SFU research team who has developed a biomechanical energy harvester (BEH) that converts mechanical energy extracted from human movement into electrical energy. Resembling a leg brace, the BEH works by acquiring the mechanical power produced by muscles at the knee joint when the user is walking. The technology is similar to regenerative braking in hybrid gas-electric automobiles; instead of dispersing mechanical energy as heat using conventional brakes, the energy is converted into electrical energy. Li’s goal is to develop a family of energy harvesting devices that can be worn on the body, inserted into motorized prostheses or permanently implanted within the body.
The medical management of human intersex: An evaluation of parent-clinician communication about treatment options
The surgical and hormonal management of intersexed children is a much more common component of pediatric care in Canada than many people realize. Intersex conditions, where noticeably atypical genitalia is deemed to require intervention, occurs in about 1:2000 live births. In the international context, driven by an increasingly well-organized coalition of intersexed people, the potentially harmful effects of these medical interventions are being debated. Proponents of standard treatment protocols justify genital surgeries with an in-the-best-interest-of-the-child rationale, claiming that to leave a child’s body in a state of sex ambiguity would inevitably lead to psychological harm and sexual maladjustment. Yet, no long-term follow up studies have been conducted to substantiate this claim. The delivery of current medical services is not structured in ways that allow for follow-up with intersexed adults, and much of the evidence from intersexed people themselves suggests that, in the long-term, the best interests of intersexed children are not protected. Many grow into adulthood feeling stigmatized and traumatized, and are left in both physiological and psychological pain by their years of medical treatment. Rodney Hunt is conducting a detailed qualitative study of parent-clinician communication to gain insight into the ways in which the current medical management of intersexed children is taken up or contested in a clinical setting. He aims to achieve a deeper understanding of the institutional and social factors that influence parent-clinician communication and decision-making when treatment options are discussed. Ultimately, Rodney’s goal is to advance current theoretical understandings of sex and gender in medicine and health policy frameworks, and to provide a valuable evidentiary base for diverse stakeholders, including clinicians, social scientists, health policy makers, intersex support groups, women’s health advocates, and those most directly affected, intersexed people and their families.
Elucidating the function of Bardet-Biedl Syndrome (BBS) proteins in Intraflagellar Transport (IFT)
Cilia are fine, hairlike projections that protrude from most cells of the human body. Many of these cilia perform sensory roles such as detecting light, sensing temperature and perceiving smell. Dysfunction of cilia is implicated in a number of conditions, most notably polycystic kidney disease. The less common Bardet-Biedl Syndrome (BBS) reflects the effects of complete loss of cilia function throughout the body. Patients with this condition suffer from obesity, polydactyly (more than 20 fingers/toes), cystic kidneys, infertility and many other conditions. Analysis of cilia structures in a tiny worm called nematode Caenorhabditis elegans has provided tremendous insight into the function of BBS proteins. Research has revealed that BBS proteins are involved in the process of intraflagellar transport (IFT), the dynamic mechanism through which cilia are built and maintained. An absence of BBS proteins appears to impair cilia function, apparently by causing the IFT machinery to split apart, although other deficiencies are highly likely. Peter Inglis has developed a new approach in studying the interaction of BBS proteins within the IFT complex, focusing on how BBS proteins are involved in the rearrangement of core IFT proteins. He will dissect BBS function and assemble a general model for the role of BBS proteins in IFT. Ultimately, his work promises to shed significant light on a cellular mechanism implicated in a wide variety of human disorders.