Control of Line Complications with KiteLock (CLiCK) in the Critical Care Unit

Health Research BC is providing match funds for this project, which is funded by the CANTRAIN-CTTP & Michael Smith Health Research BC Doctoral Studentship 2023 Award Program.  

Supported through the CANHealth Network, MITACS Accelerate, the Royal Columbian Hospital Foundation, and SterileCare Inc., CLiCK is a pan-Canadian clinical trial that investigates whether locking Central Venous Access Devices (CVADs) with 4% EDTA fluid is effective in reducing CVAD-associated complications in adult critical care patients.  

Dr. Steven Reynolds, ICU Physician at Royal Columbian Hospital, Professor at Simon Fraser University, and Executive Lead at the Advancing Innovation in Medicine Institute, is the Senior Investigator of the trial, along site Drs. Anish Mitra, Gordon Wood, Daniel Ovakim, David Forrest, Mark James, Gloria Vazquez-Grande, and Wesley Jang as Site Principal Investigators. Marlena Ornowska is the Doctoral Student working on this project.  

A CVAD is a thin tube that is inserted into one of the large, central veins of a patient. This tube allows doctors and nurses to deliver medication, fluids, blood, or nutrients directly into the bloodstream. During breaks between medications or infusions, nurses fill the inside of the tube with salt water or citrate to keep it open and ready for the next use. This is called ‘locking’ the CVAD.  

Because a CVAD is a foreign object introduced into the body, patients may develop complications such as infection and blood clots. These may be prevented by using a locking fluid has anti-bacterial and anti-thrombotic properties. One example of this type of fluid is called 4% EDTA. Our trial is investigating whether patients whose CVADs are ‘locked’ with 4% EDTA experience fewer complications than those who have their CVADs locked with salt water or citrate. This project will help us understand and create safer CVAD care in this vulnerable patient population.  

Co-creating a research agenda for health technology innovations

The sustainability of healthcare in BC hinges on innovation and technology to improve health, well-being, and independence while keeping people out of hospital. To make useful technologies we must know where they are needed, how well they work, and how to fit technology into our healthcare system. No one has all the answers. We need to bring together patients and their families, health professionals, industry leaders, engineers, researchers, and hospital administrators to identify health technology priorities and opportunities, and map a plan to move forward. We will host five workshops — one for each participant group to identify priorities, opportunities and challenges. Each workshop will result in a white paper summarizing the priorities of the group. A final co-creation workshop will include all participant groups to identify research priorities, build new patient-centered research teams, and define a pathway for these priority projects to move forward.

Team members: Andrew Sixsmith (Simon Fraser University); Sylvain Moreno (Simon Fraser University); Faranak Farzan (Simon Fraser University); Jaimie Borisoff (British Columbia Institute of Technology); Teresa Cheung (Fraser Health); Lillian Hung (University of British Columbia); Kate Keetch (Fraser Health); Chris Condin (Fraser Health); Fatemeh Khorami (Simon Fraser University); Randy McIntosh (Simon Fraser University); Swapnil Shah (BC SUPPORT Unit); Brittney Schichter (BC SUPPORT Unit); Elicia Maine (Simon Fraser University); Tania Bubela (Simon Fraser University); Mei Fang (Simon Fraser University); Delia Cooper (BC SUPPORT Unit); Clay Braziller (Simon Fraser University).