Firestorms devastated the BC communities of Kelowna, Barriere and Louis Creek in 2003. The exact impact of the psychological, economic and social disruption of the fires on the health and well-being of these communities is unknown. But research on the health consequences of natural disasters has shown that such events are associated with a variety of adverse health outcomes, including posttraumatic stress disorder and depression, and also with experiences of social and personal transformation and growth. Robin Cox is studying the disaster recovery processes in these three communities. Her goal is to develop a model of the processes that reflects the complexity of the event, taking into account the influence of public policy, economics, community cohesiveness and community identity on the physical, emotional and social well-being of people affected by natural disasters. The study will address gaps in existing disaster research by exploring the reciprocal relationships between community-level coping, individual coping and health, and by identifying individual and collective responses that foster resiliency and the adaptive capacities of people responding to trauma and stress. The results may also provide valuable information for governments, communities and disaster response agencies attempting to develop relevant and effective policies and services to support individuals and communities recovering from natural disasters.
Program: Trainee
HIV, STDs and drug use: an examination of the interplay between these factors and their influence on treatment seeking delays
Drug use, poverty, homelessness and sexually transmitted diseases (STDs) such as HIV are endemic in Vancouver’s Downtown Eastside. Melanie Rusch believes that improving the sexual health of marginalized populations is important for curbing the spread of STDs. She is studying a large sample of people who live in the Downtown Eastside to determine how behaviour patterns among these vulnerable populations affect sexual health. Her first aim is to study how different drugs and combinations of drugs affect sexual behaviours and STD rates. This includes estimating the impact of needle use, as opposed to sexual contact, on STD rates. Melanie’s second goal is to estimate STD rates of a group of women living in the Downtown Eastside. Melanie is investigating how their knowledge of STDs, exposure to outreach programs, and feelings of stigma affect use of health care services. Results of this research could be used to better define high-risk groups, identify barriers to accessing care, and tailor interventions to improve health of vulnerable populations.
HIV, STIs and massage parlour workers: application of social network analysis and mathematical modeling to assess the potential for disease propagation
Studies on the spread of sexually transmitted infections (STIs) and HIV usually focus on individual risk factors such as the number of partners and condom use. But these factors do not fully explain epidemics. Social Network Analysis, a new approach, looks at how relationships between people in defined groups affect risk of disease spread. Valencia Remple is using this approach to conduct a sexual health survey of women who work in massage parlours. As part of the study, trained peer outreach workers are conducting in-depth interviews with workers to obtain information about their sexual behaviour, histories of STIs and the characteristics of their sexual partners. She is also measuring factors known to influence the spread of STIs, such as bridging. Bridging occurs when people in one defined group have sexual contact with members of different groups, which could introduce infections into previously uninfected populations. The results of this research could be used to develop targeted health services for this vulnerable and hidden population.
Truncation of huntingtin and its relationship to the pathogenesis of Huntington's Disease
Huntington disease (HD) is a fatal degenerative brain disorder caused by a defective gene, which causes cells in specific parts of the brain to die. This leads to symptoms including progressive deterioration in the ability to control movements and emotions, recall recent events or make decisions, and leads to death 15 to 20 years after onset. One in 10,000 Canadians has HD, and children with a parent with HD have a 50 per cent risk of inheriting the disease. There is neither a cure nor treatments to prevent Huntington disease. The HD gene produces a protein called huntingtin, which breaks into short fragments that dramatically promote cell death. Little is known about the exact function and toxic properties of this mutant protein. Now Rona Graham is expanding her earlier Masters research into the mechanisms that cause shortened huntingtin. She is investigating other forms of mutant huntingtin to determine their role in creating HD, and hopes the results will lead to new therapies to prevent or alleviate this disease and other neurodegenerative disorders.
Role of alveolar macrophage proteinase genetic polymorphisms in the development of emphysema
Emphysema is a destructive lung disease that obstructs the airways and compromises oxygen transfer from the lungs to the bloodstream, causing a decrease in respiratory function. More than 1,100 people die of the disease in Canada each year. Currently, there are no treatments to cure emphysema. Cigarette smoking is the major risk factor for developing the disease. Yet only 15 to 20 per cent of smokers develop symptoms. An increase in protein-degrading enzymes called proteinases is believed to play a role in the origin of emphysema. Previous studies also suggest a genetic predisposition to airflow obstruction. Variations in the genes regulating these proteinase enzymes may be responsible for individual differences in response to cigarette smoke. Alison Wallace is researching whether genetic variants in proteinases increase smokers’ susceptibility to emphysema. If so, this information would help identify people at risk for the disease, contributing to early promotion of anti-smoking strategies and possibly leading to new methods for early detection and treatment. In addition, drugs that inhibit proteinases could be targeted to patients predisposed to emphysema, but unable to quit smoking.
Early progression and detection of ovarian cancer
In developed countries, ovarian cancer is the leading cause of death from gynecologic malignancies in women. The five-year survival rate is only 35 to 40 per cent, a rate that hasn’t changed significantly in 25 years. The poor prognosis is due to the lack of a reliable test for early detection and the inability to identify early symptoms of the disease, which means the majority of ovarian tumours are diagnosed at an advanced stage. During progression to malignancy, normal ovarian surface epithelial cells, which give rise to the majority of epithelial ovarian cancers, acquire more complex and highly differentiated characteristics that most often resemble epithelial cells in the fallopian tube and uterus. This change may provide an advantage for growing cancer cells. Michelle Woo is screening ovarian tumour tissues for markers known to be present in the fallopian tube and uterus. She has recently discovered a protein in ovarian tumours that may be an early indicator of ovarian cancer. Another approach she is using to examine early changes in ovarian tumour progression involves the use of a unique three-dimensional culture system to mimic the development of ovarian tumours in women. Michelle hopes this research will identify new predictive markers that can be used for early screening and prevention of ovarian cancer.
Game on: diminishing risks for depressive symptoms in early adolescence through positive involvement in team sports
In early adolescence, both girls and boys report increases in levels of depression. However, by late adolescence the rates of depression among girls are double those found among boys. Research shows that boys and girls’ perceptions about athletic competence (how good they are at sports), social acceptance (how popular they are among peers), and body dissatisfaction (negative feelings about their bodies) are strong predictors of depression. Since girls tend to report lower levels of athletic competence, participate in sports at lower rates, and report higher levels of body dissatisfaction than boys, they may be at greater risk for depression. Erin Boone is examining whether positive involvement in team sports increases perceptions of athletic competence and social acceptance, and helps to diminish body dissatisfaction among both girls and boys. The study will be among the first to assess the mechanisms that link positive team sports involvement to diminished risks for depression in adolescence. Findings will outline the mental health benefits associated with team sports involvement and highlight the need to sustain adolescents’ interest and participation in sports.
Molecular analysis of transplant recipients
One of the major problems for patients who have undergone heart or other transplants is the potential for the body’s own immune system to attack the newly introduced organ. As a result, patients must take large doses of immunosuppressive drugs daily to prevent rejection of the new organ, which the body perceives as foreign. Unfortunately, these medications interfere with normal immune response, which leads to a wide range of dangerous side effects, including higher susceptibility to infections and cancer. Dosage must be carefully monitored: not enough, and the body will begin to reject the organ; too much, and patients must deal with the serious side effects. The goal of Edward Chang’s work is to develop new genetic tests to predict exactly how much medication each individual patient requires to ensure the organ is accepted with minimal side effects.
Identification of genes key to the progression of squamous cell carcinoma of the lung by 3p array comparative genomic hybridization
Lung cancer accounts for the majority of cancer deaths in Canada. Unfortunately, diagnosis typically occurs after lung cancer is well-established, too late for effective treatment. To develop more effective ways of detecting and treating cancer, researchers are studying the genetic makeup of patients, with the goal of identifying and characterizing particular genes that may either suppress or promote the onset and progression of lung cancer. Using an approach that combines laboratory benchwork with bioinformatics techniques (the use of computer tools and databases to analyze large amounts of biological data), Bradley Coe is focusing his work on a specific chromosome, 3p, with which genetic alterations have recently been linked to the development of lung cancer. Identifying genes critical to the disease process will lead to a better overall understanding of lung cancer and may point the way to more targeted diagnostic tests and treatment.
Cellular excitation contraction coupling of intact airway smooth muscle
Diseases of the airways, such as asthma, are often characterized by excessive constriction of tissues caused by the over-contracting of smooth muscle cells. This contraction can severely impair breathing and compromise oxygen exchange between the lungs and blood system. Calcium is a major activator of smooth muscle cell contraction, and the concentration of calcium within cells determines the extent of contraction. Using intact airway muscle tissues, Jiazhen Dai is undertaking an extensive survey of the pattern and the mechanisms of calcium-dependent contraction in both healthy and diseased airways. In particular, she will investigate a newly-uncovered pattern of asynchronous, wave-like calcium oscillation to assess its role in airway constriction. This research will provide a better understanding of the mechanisms of airway constriction and ultimately, new drugs to effectively treat respiratory conditions such as asthma.