CD-based ELISA for point-of-care diagnostics
…In contrast, point-of-care diagnostic tools allow testing and diagnosis to be performed in a doctor’s office, at a significantly reduced cost and in a shorter time to obtain test results….
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Treating breast cancer with a novel programmable fusogenic gene delivery system for small interfering RNA targeting integrin-linked kinase
…by issues related to the way the drug is delivered to the tumour. Dr. Emmanuel Ho is working to develop and test a novel method to deliver the drug only…
Development of a novel prognostic model in Follicular Lymphoma
…develop and test a diagnostic model that can be translated into clinical tests for use by hospital laboratories. Her project seeks to move novel biomarkers into the forefront of outcome…
Pharmacogenomics of anthracycline-induced cardiotoxicity in childhood
…he will conduct a number of studies to confirm that the identified gene variants are the “culprits.” Visscher plans to create a diagnostic test based on the variants that can…
Studies toward the total synthesis of the analgesic natural product chimonanthine and its analogues
…determining the most efficient and cost-effective way to synthesize the molecules. He and colleagues will collaborate with a pharmaceutical company to test the analogues in pre-clinical trials, determining modifications to…
T Cell Therapy of Breast Cancer; Challenges and Opportunities
…these T cells, and test whether she can disrupt the tumour environment to facilitate the effective infiltration of T cells. The information gathered from Martin’s genetic analysis of infiltrated and…
Encapsulation based in vitro selection of RNA catalysts
…important metabolic functions that are currently performed by protein enzymes. I am developing in vitro (in the test tube) techniques to isolate new RNA catalytic molecules. Because these artificially manufactured…
Investigation of the apolipoprotein C-II activation site of human lipoprotein lipase
…activate LPL. I will put the portions of LPL we think are responsible for activation into HL to test whether HL is activated and confirm that this part of LPL…
Children’s mental health: Linking research evidence and policy making
How can we ensure that public policies in children’s mental health reflect the best available research evidence about what works to help children. This is the research focus for Dr….
Shaping the outcome of viral-mediated autoimmune myocarditis
…following viral infection contribute to development of chronic heart disease. He will use findings from the study to design and test new methods to prevent heart disease, which could also…