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…mutant huntingtin (muHtt). Symptoms of the disease include cognitive impairment, motor dysfunction and psychiatric disturbances that usually develop around midlife. Many treatments are under investigation in mouse models of HD…
Motor control deteriorates with age. For example, people over the age of 65 commit more traffic errors than younger drivers. However, it remains unclear the extent to which this increased…
…research is done with a small sample of workers in a controlled test environment. However, in order to have representative and generalizable results about the risk of injury, researchers require…
…(silencing) of specific genes that promote cancer growth. Ultimately, this weakens the cancer cells to cause cell death or make cancer cells more vulnerable to radiation and/or chemotherapy. One promising…
Lymphoid cancers are the fourth most common cancers in Canada. The incidence of follicular lymphoma (FL), a common and incurable subtype of lymphoma, continues to rise and represent an important…
…many children and adults with cancer. However, they can sometimes be very harmful or damaging to the heart (cardiotoxicity), resulting in life-long drug treatment, the need for heart transplantation, or…
The enzymes hepatic lipase (HL) and lipoprotein lipase (LPL) play a key role in the metabolism of cholesterol and fat circulating in the blood stream. However, their specific role and…
…HD is now known and the mutant HD gene produces an abnormal protein called huntingtin (htt) that damages brain cells. Many research groups around the world are studying how the…
…system (nose) to study CNS repair because cells in the system have a remarkable ability to remodel, repair and regenerate, compared to other regions of the CNS. Olfactory system repair…
To develop a system for identifying objective safety-related outcome measures to assist in the design, implementation and evaluation of organizational changes (culture, human resources, care processes, etc) that will improve…