Roland Scholz

Dr. Roland Scholz completed his degree in biochemistry at the University of Regensburg, Germany, and the University of Colorado at Boulder, USA, with main focus on the molecular biology of adenovirus infection. Following subsequent training at the Max Planck Institute of Biochemistry, Germany, he received his PhD from ETH Zurich, Switzerland.

In his PhD training, Dr. Scholz studied the regulatory control of hetero-oligomeric protein kinase complexes. Currently, he is a post-doctoral trainee in the laboratory of Dr. Brett Finlay at the University of British Columbia. Combining his expertise in cellular signaling and infection biology, Dr. Scholz aims to unravel the role of post-translational protein modifications in the infection process of the human pathogens enteropathogenic and enterohemorrhagic Escherichia coli. To achieve this goal he employs a multidisciplinary approach, which integrates methods from systems biology, biochemistry, cell biology, microbiology and immunology.

By understanding the complex molecular interplay between the pathogen and its host, Dr. Scholz aims to provide the basis for novel therapeutic approaches.

Recent Publications

Sal-Man N, Setiaputra D, Scholz R, Deng W, Yu AC, Strynadka NC, Finlay BB. EscE and EscG are cochaperones for the type III needle protein EscF of enteropathogenic Escherichia coli. J Bacteriol. 2013 Jun;195(11):2481-9. doi: 10.1128/JB.00118-13. Epub 2013 Mar 22. (PubMed abstract)

Sal-Man N, Biemans-Oldehinkel E, Sharon D, Croxen MA, Scholz R, Foster LJ, Finlay BB. EscA is a crucial component of the type III secretion system of enteropathogenic Escherichia coli. J Bacteriol. 2012 Jun;194(11):2819-28. doi: 10.1128/JB.00103-12. Epub 2012 Mar 23. (PubMed abstract)

Scholz R, Sidler CL, Thali RF, Winssinger N, Cheung PC, Neumann D. Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem. 2010 Aug 13;285(33):25753-66. doi: 10.1074/jbc.M109.093468. Epub 2010 Jun 10. (PubMed abstract)

Scholz R, Suter M, Weimann T, Polge C, Konarev PV, Thali RF, Tuerk RD, Viollet B, Wallimann T, Schlattner U, Neumann D. Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix. J Biol Chem. 2009 Oct 2;284(40):27425-37. doi: 10.1074/jbc.M109.047670. Epub 2009 Aug 3. (PubMed abstract)

Sieber T, Scholz R, Spoerner M, Schumann F, Kalbitzer HR, Dobner T. Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R. Virology. 2011 Sep 30;418(2):133-43. doi: 10.1016/j.virol.2011.07.012. Epub 2011 Aug 17. (PubMed abstract)