Jessica Rosin

The processes governing proper development of the embryo are being recognized as increasingly complex in nature and highly sensitive to the maternal environment. Our laboratory seeks to understand how immune cells such as macrophages contribute to craniofacial morphogenesis. During pregnancy disrupting macrophage functions results in craniofacial and dental abnormalities. To explore the developmental contribution of these immune cells to the craniofacial region, we use our established pharmacological mouse model alongside state-of-the-art expression profiling and imaging technologies. By studying how macrophages contribute to normal development of craniofacial tissues, this research will lead to advancements in our understanding of how maternal insults like maternal periodontal infection–a prevalent condition associated with adverse pregnancy outcomes–disrupts developmental programs. Overall, this research will broaden our knowledge of maternal-fetal interactions to benefit healthcare professionals and pregnant women.