Dr. Efthymios Kyriakis is intrigued by the way structural biology can answer how macromolecules interact, function and are regulated in order to create and maintain life. He received his PhD in 2020 from the Department of Biochemistry and Biotechnology at the University of Thessaly in Greece. Efthymios’s PhD was balanced between structural and functional biochemistry, aiming to elucidate protein crystal structures in complex with small molecules that could serve as anti-hyperglycæmic agents for Type 2 diabetes treatment using X-ray crystallography.
Currently, he is a postdoctoral fellow at the University of British Columbia applying cryogenic electron microscopy to investigate the binding of small molecules on KCNQ1, a protein whose dysfunction can result in arrhythmia and sudden death. Efthymios’s work aims to help unravel KCNQ1 regulation and to contribute to the development of potential therapeutic agents.
For an up-to-date list of Efthymios’s publications, see ORCiD.