The contribution of metabotropic glutamate receptor 5 (mGluR5) to impaired control of brain blood flow in Alzheimer’s disease

Alzheimer’s disease is a major crisis and a huge burden on healthcare system. It causes a decrease in memory and affects women more than men. The memory decline in Alzheimer’s is linked to poor blood supply to the brain. The causes for poor supply are unknown but it starves brain cells of essential materials leading to improper function. I will study how a molecule present in the cells of the brain called metabotropic glutamate receptor 5 (mGluR5) contributes to the poor blood supply to the brain and the development of Alzheimer’s symptoms. My group at UBC is interested in mGluR5 because it attaches to the “toxic molecules” commonly found in Alzheimer’s brain. I will use mice sick with Alzheimer’s and samples from Alzheimer’s patients to study how the attachment of the “toxic molecules” to mGluR5 can lead to the short supply of blood to the brain and memory loss. I will also study if the role of mGluR5 in Alzheimer’s is different between males and females. In addition, I will test if the drugs that act on mGluR5 can help Alzheimer’s patients by correcting blood supply to the brain and improving memory. I also will work with patient and community partners to help interpret and communicate my findings and guide future work.