Chronic Obstructive Pulmonary Disease is a progressive lung disease that causes breathing difficulties and chronic cough. Those affected often have weak arm and leg muscles that are easily fatigued, which can cause them to avoid exercise and adopt an inactive lifestyle. Dr. A. William Sheel’s research is directed at understanding how reduction in blood flow and oxygen during exercise leads to muscle fatigue and how different types of exercise affect the amount of fatigue. Results from his study will help explain why people with chronic lung disease become prematurely fatigued and could be used to design exercise rehabilitation programs to improve their health.