Human neuraminidase enzymes as therapeutic targets in skin inflammation

Chronic skin inflammation (CSI) includes two major groups of conditions: psoriasis, and atopic dermatitis (eczema) that, together, affect up to 6% of the population worldwide. Both diseases are characterized by a chronic and non-curable symptom. White blood cells in both diseases produce signalling molecules that trigger local inflammation. Using mouse models, we found that a human enzyme, neuraminidase 1 (NEU1), may play an essential role in inflammation of the skin.

In this project we will investigate the role of enzyme, NEU1, in chronic inflammatory diseases of the skin. We will investigate the mechanism of inflammation in skin diseases like psoriasis and the role of NEU1 using genetic knock-outs. Using previously developed inhibitors of NEU1, we will test if pharmacological strategies could be used as therapeutics. To learn more about the mechanism of skin inflammation in humans, we will use an in vitro model of human skin to examine the role of the NEU1 enzyme in inflammation. These studies will expand our understanding of the role of glycosylation in mechanisms relevant for in psoriasis and atopic dermatitis and could lead to new clinical strategies for these diseases.