Nerve transfer surgery to restore upper-limb function after cervical spinal cord injury

One of the most devastating consequences of cervical spinal cord injury (cSCI) is the loss of hand movements, which severely impacts independence and quality of life. Nerve transfer surgery (NT) is emerging as a promising method to restore functions like hand opening and closing. While previous research shows NT is safe and potentially effective, robust scientific evidence of the effectiveness of NT is lacking. To address this gap, a national collaborative effort led by BC-based physiatrist and clinical assistant professor Dr. Michael Berger is conducting the first multi-centre prospective study on NT for individuals with cSCI (https://clinicaltrials.gov/study/NCT05638191). The primary aims of this study are to evaluate NT’s overall effectiveness in individuals with cSCI, identify patient subgroups most likely to benefit from NT based on factors like age and injury level, and explore patients’ lived experiences post-surgery. This study, supported by the CANTRAIN-CTTP & Michael Smith Health Research BC Post-Doctoral Fellowship 2024 Award Program, is being conducted across four Canadian interdisciplinary clinical programs (Vancouver, BC; Toronto, ON; Kingston, ON; Halifax, NS). Over four years, participants will undergo comprehensive assessments at baseline and regular intervals for 24 months post-surgery, enabling researchers to track changes in functional, motor, and patient-reported outcomes. By rigorously evaluating the efficacy, safety, and broader impacts of this innovative surgical technique, our team aims to provide individuals with cSCI the knowledge and confidence to make informed decisions about their treatment options.