Jai Mahto

I am deeply passionate about advancing my expertise in the field of structural biology and am currently pursuing an opportunity in cryoEM of retinal macromolecular complexes to further enrich my expertise in the field. Our lab is dedicated to uncovering the structure of retinal guanylate cyclase (RetGC), a pivotal protein in the phototransduction process. Mutations in RetGC have been linked to a range of vision disorders, from rod cell dysfunction to the progressive degeneration of both rods and cones. By elucidating the structure of RetGC, we aim to identify the structural changes caused by these mutations and explore potential therapeutic interventions that could help restore vision.
During my doctoral research, I focused on identifying novel enzymes and elucidating their structure-function relationships to enhance the degradation of plasticizers. My work led to the identification of four plasticizer-degrading enzymes and demonstrated how these enzymes could be rationally engineered for improved degradation efficiency. This research has contributed to advancing environmental sustainability by providing insights into enzyme engineering for pollutant degradation.