This award supports the creation of a team to study how muscle in elderly people with chronic conditions responds to rehabilitative exercise protocols designed to optimize function and decrease disability. The RAMP team aims to develop an integrated research strategy that spans from cellular to clinical rehabilitation research. The strategy will include consideration of how co-existing conditions, such as chronic respiratory or heart disease, affect muscle response to exercise. The overall goal is to develop safe and effective exercise programs that elderly people will find appealing and be able to adhere to.