Acute intermittent hypoxia as a treatment of diabetic-induced sensory neuropathy, wound healing deficits, and motor system decline

Knowledge gap: Diabetes is a leading cause of amputation because it causes nerve damage (numbness, pain), skin wounds (infections), muscle loss (weakness), and bone thinning (fractures, osteoporosis). Acute intermittent hypoxia (AIH, breathing cyclical low & normal oxygen levels x2 hours) promotes healing and treats other diseases of the nervous system. We believe AIH will improve the effects of diabetes on the nerves, skin, muscle, and bone of the leg.

Aim 1 (Rodent Model): we will investigate if AIH treats nerve, skin, muscle, and bone of the diabetic leg. Animals with diabetes treated with AIH will be compared to no-AIH controls using behaviour testing, specialized imaging, and assessment of tissue samples.

Aim 2 (Clinical): we will investigate if AIH improves recovery of sensation, decreases pain and improves wound healing for human patients with diabetes. Fifty patients will be recruited from the multidisciplinary lower limb reconstruction program for inclusion.

Expected Outcomes: Based on preliminary data, we believe AIH is a safe and effective strategy to treat the diabetic leg.

Impact: Without the need for surgery or medications, AIH may provide treatment for diabetic patients to treat pain, infection and amputation.