Design and screen novel cell-penetrating peptides for intracellular delivery of proteins

Aim: Our industry partner Sinedore Bioscience has licensed our cell-penetrating peptide technology from UBC, aiming to improve intracellular delivery of protein drugs. Based on the lead peptide sequence, Sinedore aims to develop novel and enhanced CPPs to further improve the drug delivery efficiency. Sinedore will use the UBC data to train their computing model, which will suggest new CPP sequences that are anticipated to outperform the lead. The UBC team will synthesize the new peptides, perform cell-based assays, and provide the data to refine the model, aiming to develop an enhanced CPP.

Skills expected to develop: peptide synthesis using a peptide synthesizer; cell-based assays; computer modeling; oral presentation; manuscript writing

Impact: The project will lead to the development of novel and enhanced CPP to improve intracellular delivery of protein drugs. An intern will receive cutting-edge training on computational modeling and delivery of proteins, eventually contributing to the sustainability and growth of the health sector of BC.