Re-purposing the ordering of ‘routine’ laboratory tests in hospitalized medical patients (RePORT)

Blood tests can help diagnose diseases and monitor health status. However, overuse of blood testing, particularly in hospitals, leads to patient discomfort, loss of sleep, contributes to blood loss leading to blood transfusions, and wastes health care dollars. We previously developed and tested a multi-part healthcare provider (HCP) engagement strategy to safely reduce overuse of six target laboratory tests that make up 40 percent of costs on laboratory testing in hospitalized medical patients. In collaboration with a Patient and Family Advisory Council (PFAC), we have co-designed a patient engagement strategy that includes an infographic, video and website. Our team, made up of clinicians, researchers, patient partners and policy makers, proposes to launch the HCP and patient engagement strategies across 16 hospitals in British Columbia and 14 hospitals in Alberta in a cluster randomized stepped-wedge design. We will evaluate the impact of this strategy on number of laboratory tests done, patient experience, patient safety, costs and HCP experience, using administrative data systems and patient and HCP interviews. We will work with the PFAC to design implementation evaluation, particularly of the patient engagement strategy.

FIRE-Diet: food as an intervention to reduce effects of woodsmoke exposure on respiratory health

Many people in BC are exposed to woodsmoke from woodburning stoves in their homes, controlled burning for farming purposes, and increasingly from wildfires. Exposure to woodsmoke can lead to difficulty breathing, lung disease, hospitalizations, and in some people who have underlying health conditions, even death. Children, whose lungs are actively developing, may be at heightened risk. We don’t yet fully understand how woodsmoke causes health effects nor how to reduce or prevent these effects in people who can’t avoid exposure. We want to find these answers, first by examining symptoms and changes in function and immune activity in the lung with exposure to woodsmoke. We will also study whether and how the impact of woodsmoke may differ by (1) age of exposure, including developmental windows in childhood, (2) female or male sex, and (3) genetic factors, so that we can design strategies to protect and help those with the greatest and most urgent need. Lastly, because of growing evidence that a healthier diet may help the body to protect itself from pollution, we will study whether a person’s diet changes the effects of woodsmoke on the lung. This work will be performed at UBC with partners across BC and Canada.

Clinical Trial for Montbretin A (MbA) in Diabetics

Health Research BC is providing match funds for this research project, which is funded by GlycoNet’s Translational Grant

 

This fully B.C.-based project will undertake a Phase 1 human clinical trial of a promising natural product from plants, Montbretin A (MbA), for control of blood glucose levels in diabetics. The team comprises a chemist (Stephen Withers), a clinician (Robert Petrella), a plant biochemist (Joerg Bohlmann) and a biochemist/coordinator (J.P. Heale). Earlier B.C. work identified MbA as a potent inhibitor of amylase, the principal human enzyme that degrades starch in our guts leading to glucose release into the bloodstream. Subsequent studies in diabetic rats confirmed that orally administered MbA lowers blood glucose levels and is safe, even at very high dosages. On this basis Health Canada approved a Phase 1 clinical trial to evaluate the safety of MbA in humans. This funding will allow us to carry out that trial in a side-by-side evaluation with the drug acarbose that is currently used but causes unpleasant side effects. Due to its different mode of action of MbA should be better tolerated yet highly active.

 

Key words: diabetes, obesity, blood glucose, amylase, inhibitor

Mind the gap: Hormonal contraceptives and the brain

Hormonal contraceptives (HC) are used by 850 million girls, women and people with uteri — all reflected in the term women+ — , and 16 percent of people (5-49Y) in Canada. In addition to being contraceptives, HCs are prescribed off-label to treat many other conditions. Few studies have examined effects of these hormones on the brain; however, recent work suggests they can increase risk for mood disorders during adolescence and alter brain activation patterns. Yet, how HC use may influence long-term brain health is not known. Understanding brain health, especially through an equity lens, is critical. Women+ experience different brain health symptoms as a result of their unique experience of stress, which is impacted by age, gender, and race/ethnicity. Stress outcomes affect disease risk, which is also influenced by HCs. Collaborations between academics and research users are vital to understanding the unique ways that women+’s lives impact their brain health. This conference will explore how HCs influence women+’s brain health by bringing together researchers, clinicians, community partners, trainees, and policymakers to exchange knowledge and identify new research priorities that fill knowledge gaps and address patient experiences.


Team members: Katherine Moore (Women’s Health Research Cluster); Jesse Lacasse (Concordia University); Bonnie Lee (UBC); Jennifer Williams (McMaster University); Maureen MacDonald (McMaster University); Nafissa Ismail (University of Ottawa); Elizabeth Hampson (University of Western Ontario); Gillian Einstein (University of Toronto); Frances Chen (UBC); Sofia Ahmed (University of Calgary).

Improving access to breastfeeding support in interior British Columbia: A collaborative planning project

While breastfeeding has many health benefits for both infant and mother, many women and birthing people experience breastfeeding challenges. Insufficient supply, poor latch, and pain, as well as stigma and lack of support can impact breastfeeding goals. These challenges can be heavily influenced by social inequities, parental leave, and societal pressures, particularly among disadvantaged populations in Canada. It is important for postpartum people to receive breastfeeding support from healthcare professionals, especially during public health emergencies like the COVID-19 pandemic, where in-person contact is limited. Therefore, this C2 project will establish key networks and resources around optimal breastfeeding support in interior BC. Specific objectives are to build partnerships, conduct a needs assessment, and co-create a research agenda to develop and evaluate a virtual breastfeeding intervention study in this region. We expect to identify key aspects of virtual support that will create a thorough and meaningfully designed breastfeeding intervention study, which will ultimately lead to higher rates of breastfeeding rates, as well as improved user satisfaction and self-efficacy among parents and families in BC.


Team members: Elizabeth Keys (UBC – Okanagan); Rishma Chooniedass (UBC – Okanagan); Michele Hopkins (The Bridge Youth & Family Services); Ellen Boelcke (KCR Community Resources); Olivia Andrews (UBC – Okanagan).

Acts of kindness as an antidote to social disconnection: Development and dissemination of an online intervention program to increase social engagement in BC neighbourhoods

Loneliness and social isolation have been increasingly recognized as a growing public health priority with extensive evidence that these issues take a significant toll on population health. Despite this escalating urgency, exacerbated by the COVID-19 pandemic, effective evidence-based interventions for mitigating social isolation and loneliness are lacking. Based on previous research by UBC researchers, this project proposes “acts of kindness” as an antidote to social disconnection. Our teams at UBC and UWBC will partner to co-develop and test the effects of an online intervention program to promote social connection in lonely BC residents. We expect that this project will provide an accessible, easy-to-implement program that will mitigate the isolation felt by participating BC residents in the periphery of social networks while also reducing the spread of loneliness throughout those BC residents’ social networks. We also expect this project will promote evidence-based approaches to tackle public health issues in the BC community extending beyond the issue of loneliness, so that UWBC (research users) can ensure that effective and high-quality programs reach British Columbians (ultimate research beneficiaries).


Team members: Jasica Grewal (United Way of BC); Tobias Jones (United Way of BC); Yeeun Archer Lee (UBC); Julia Nakamura (UBC); Rachel Hamilton (UBC).

Group sense making and model building for mapping systems for the promotion of population physical activity in British Columbia

The COVID-19 pandemic and climate crises highlighted the need for renewed and strengthened systems to promote population physical activity (PPA) in BC. This need, coupled with calls for using complex systems methods, forms the basis for the proposed activities. Complexity can be seen as the context where numerous interacting elements (i.e. people, entities) in a system make it hard to see, describe, and assess what is happening in the whole. Complex systems methods are a way to gain clarity on complex problems by focusing on the patterns of what the system does or how it behaves. After the completion of a formative scoping review and interviews with stakeholders to assess the current state of systems for PPA in BC, we now plan to invite partners and stakeholders from many sectors and facilitate online group sense making sessions. These sessions will involve participatory processes to develop understanding of the current state of the systems for PPA. A second session will focus on identifying directions for strengthening systems for PPA in terms of policy, practice and research. The project team will provide recommendations for potential roles and responsibilities for the BCCDC to strengthen systems for promoting PPA.


Team members: Drona Rasali (BCCDC); Lori Baugh Littlejohns (BCCDC); Geoff McKee (BCCDC); Daniel Naiman (BC Ministry of Health).

Building partnerships for improving chronic pelvic pain care in gynecology: A needs assessment of health professionals-in-training

Chronic pelvic pain affects ~15 percent of women and an unknown number of gender diverse people. Despite its common and devastating effects, chronic pelvic pain is too often dismissed or mismanaged, which is in part due to physicians’ lack of education on the topic. This study will identify knowledge needs about chronic pelvic pain of BC health professionals-in-training, which will guide the development of a future online resource. To do this, we will 1) Convene a group of experts interested in improving education and care for people with chronic pelvic pain; 2) Assess the knowledge level and attitudes towards chronic pelvic pain in gynecology using a baseline survey completed by medical and nurse practitioner students; and 3) Collaborate with experts to review the needs assessment and co-create a plan for a future resource. We aim to improve the understanding of chronic pelvic pain in health professionals-in-training and ultimately improve care for people with this complex condition by addressing the specific knowledge needs and identifying meaningful information to be included in a future resource to address gaps in medical education.


Team members: Natasha Orr (UBC – School of Nursing); Paul Yong (UBC – Faculty of Medicine); Leanne Currie (UBC – School of Nursing); Karim Qayumi (UBC – Faculty of Medicine); Margaret Carlyle (UBC – Okanagan; Faculty of Arts & Social Sciences, Department of History and Sociology); Rachel Langer (UBC – Endometriosis and Pelvic Pain Laboratory); Lan Randhawa (UBC – Endometriosis and Pelvic Pain Laboratory); Helena Daudt (Pain BC); Jennifer Krist (UBC – School of Nursing).

Remission Possible: A knowledge translation project to inform British Columbians with Type 2 diabetes that remission is possible

Type 2 diabetes (T2D) is traditionally viewed as a chronic, progressive condition that someone has for life. Our research, and that of others, now shows it is possible to drive T2D into remission through specific diet and lifestyle changes. T2D remission means that blood sugars are back in the normal range with no medications needed; it represents a new way of viewing T2D which provides hope for those affected. Research shows T2D remission is achievable, but now we need a public outreach program to alert as many British Columbians as possible to this news and connect them with helpful resources. We will implement a KT initiative including: 1) Video and graphic media products that we create; 2) Earned mainstream media coverage; and 3) A social media campaign, which amplifies the first two elements and drives viewers to a web platform, RemissionPossible.ca, which will connect them with T2D remission resources. Given how broadly T2D affects British Columbians and what a “feel good” story this is, we anticipate significant interest with mainstream and social media. By carefully tracking results (impressions and web traffic), we will improve our reach and learn valuable lessons to inform future KT initiatives.


Team members: Damien Gillis; Barbara Oliveira (UBC Okanagan); Tom Elliot (UBC); Sean McKelvey (Institute for Personalized Therapeutic Nutrition, not-for-profit); Marc Pelletier (Institute for Health Systems Transformation and Sustainability, not-for-profit); Deanne Taylor (Interior Health); Kathleen Martin Ginis (UBC Okanagan and Centre for Chronic Disease Prevention and Management); Krista Lamb; JJ Belanger; Chris Xi.

Knowledge translation and mobilization to support exercise recommendations for people with bone metastases

The objective is to develop a knowledge translation and mobilization plan for exercise recommendations for people with bone metastases. In advanced cancer, cancer can spread to bone, called ‘bone metastases’. This makes bones weaker and more likely to break, leading to pain and disability. Physical activity can help people living with bone metastases to maintain their independence and engage in more activities they enjoy. However, health care professionals, exercise professionals and people living with bone metastases (user groups) are uncertain about how to safely engage in physical activity. In 2022, expert recommendations were published on physical activity specifically for people with bone metastases. Without specific tools for user groups and communication plans, it could take years for these recommendations to be taken up into practice. We will bring together people who are part of the intended user groups across British Columbia to “co-design” the best way to get information about the recommendations to people who need it, in the most useful way possible. This project aims to raise awareness about the recommendations and start the process to increase use of the recommendations for people living in British Columbia.


Team members: Christine Simmons (BC Cancer Agency); Alan Bates (BC Cancer); Cathy Clelland (BC Cancer); Sian Shuel (BC Cancer); Leah Lambert (BC Cancer); Sarah Budding Smith (BC Cancer); Chiara Singh (Fraser Health & Physiotherapy Association of British Columbia); Hardip Jhaj (British Columbia Association of Kinesiologists); Rebecca Tunnacliffe (BC Recreation and Parks Association); Tracy Torchetti (Canadian Cancer Society); Sarah Weller (BC Cancer); Stephanie Skourtes (Women’s Health Research Institute); Kirstin Lane (Exercise Science, Physical & Health Education University of Victoria); Sarah Neil-Sztramko (National Collaborating Centre for Methods and Tools); David Langelier (University of Toronto and Princess Margaret Cancer Centre); Michelle Nadler (Princess Margaret Cancer Centre); Samantha Myers (UBC – Rehabilitation Sciences).