Disease-modifying Drug Safety and Effectiveness in Multiple Sclerosis [DRUMS]
…drugs used to treat MS are when used in the everyday, real world in BC and Canada. To achieve these study goals, I have two main study Themes. The first…
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Pharmacogenomic prediction of anthracycline-induced cardiotoxicity
…failure. Dr. Aminkeng aims to identify genetic markers that can predict anthracycline-induced cardiotoxicity and congestive heart failure using a genome-wide association study (GWAS). The goal is to develop a clinical…
ASK JEAN: What is a UTN?
…Registry Platform (ICTRP) was formed by the World Health Organization (WHO), with the endorsement of its member countries, to identify a trial regardless of multiple registration records. The new international…
Regulatory update: Spring 2022
Health Canada Modernization update and ICH E8(R1) General Consideration for Clinical Studies. Clinical Trials BC Chronicle Spring 2022 – by Jean Smart, regulatory affairs & quality officer, Clinical Trials BC…
Children’s mental health: Linking research evidence and policy making
…health problems that affect their emotions, learning and behaviour, and interfere with their development. This creates a large burden of suffering for these children, their families and their communities. However,…
Structural exploration of locked nucleic acids (LNAs) for incorporation into anticancer oligonucleotides
…made up of chains of nucleotide units, but to make them useful as drugs, these nucleotides have to be structurally changed. Locked nucleic acids (LNAs) are a very useful type…
2018: Funding the research talent BC needs
…researchers, government representatives and not-for-profit organizations to discuss how research can inform health policy. We also launched our new Implementation Science Team (IST) Program to support the study of proven…
Structural dynamics of hERG potassium channel gating studied using voltage clamp fluorimetry
…associated with the heart beating. Voltage-gated potassium channels, such as the human ether-a-go-go related gene (hERG). are a class of ion channels that open and close – an action known…
Chemical suppression of nonsense mutations for the treatment of frontotemporal dementia
…effective combination. This approach, also referred to as “suppression of nonsense mutations”, offers the possibility of developing a new drug for patients with frontotemporal dementia cause by a progranulin mutation….
Molecular determinants of pathogenesis and clinical outcomes in high-grade B-cell lymphoma
…to understand how these lymphomas develop in the body. This new knowledge will help design smarter therapies that target the tumour while sparing normal body cells. These ‘targeted therapies’ can…