Menno Oudhoff

After finishing his PhD in Amsterdam, where he studied saliva-derived peptides that help wound healing, Dr. Menno Oudhoff started in the lab of Dr. Colby Zaph at the UBC-based Biomedical Research Centre. His initial focus was on intestinal helminth infection, but he soon became interested in the cellular pathways that control regeneration and cancer. His current project focuses on how these pathways are controlled by post-translational modifications.

Dr. Oudhoff tries to combine biochemistry and microscopy to deduct the molecular mechanism with in vivo disease models, which hopefully will make his studies clinically relevant. Although he firmly believes that the discoveries made in basic science are the fuel for future therapeutics, cellular mechanistic studies preferably should be combined with in vivo models.

Recent Publications

Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, Zaph C. Control of the hippo pathway by set7-dependent methylation of yap. Dev Cell. 2013 Jul 29;26(2):188-94. doi: 10.1016/j.devcel.2013.05.025. Epub 2013 Jul 11. (PubMed abstract)

Bolscher JG, Oudhoff MJ, Nazmi K, Antos JM, Guimaraes CP, Spooner E, Haney EF, Garcia Vallejo JJ, Vogel HJ, van’t Hof W, Ploegh HL, Veerman EC. Sortase A as a tool for high-yield histatin cyclization. FASEB J. 2011 Aug;25(8):2650-8. doi: 10.1096/fj.11-182212. Epub 2011 Apr 27. (PubMed abstract)

Oudhoff MJ, Kroeze KL, Nazmi K, van den Keijbus PA, van ‘t Hof W, Fernandez-Borja M, Hordijk PL, Gibbs S, Bolscher JG, Veerman EC. Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1,000-fold. FASEB J. 2009 Nov;23(11):3928-35. doi: 10.1096/fj.09-137588. Epub 2009 Aug 3. (PubMed abstract)

Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van ‘t Hof W, Amerongen AV, Veerman EC. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. 2008 Nov;22(11):3805-12. doi: 10.1096/fj.08-112003. Epub 2008 Jul 23. (PubMed abstract)

de Jong MA, de Witte L, Oudhoff MJ, Gringhuis SI, Gallay P, Geijtenbeek TB. TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo. J Clin Invest. 2008 Oct;118(10):3440-52. doi: 10.1172/JCI34721. (PubMed abstract)