Per- and polyfluoroalkyl substances (PFAS) contamination represents a growing global health and environmental concern due to their persistence, toxicity, and widespread distribution. Addressing this challenge, a novel small-scale photoelectrocatalytic system utilizing titanium dioxide nanotube arrays has been developed. This system efficiently degrades a wide range of PFAS into environmentally benign byproducts such as CO? and fluoride ions. Operable with minimal electrical input, it mitigates risks of long-term contamination and corrosion while maintaining energy efficiency. The applied voltage in the system minimizes energy losses from undesired side reactions, ensuring optimal catalytic performance. The versatility of this technology makes it suitable for applications such as wastewater treatment and soil washing, offering a scalable and sustainable solution for PFAS remediation. The research aims to investigate critical parameters for scaling up this technology, including its interaction with contaminated filtration media and the longevity of the catalysts under challenging environmental conditions. Insights gained will contribute to optimizing system performance and assessing its feasibility for large-scale deployment in diverse contaminated environments. By advancing the understanding of this innovative system’s operational limits and efficiency, this study seeks to address one of the most pressing pollution challenges of our time, providing a pathway toward effective PFAS contamination management and environmental restoration.